TUFTS University di Boston, USA

IL-38 inhibits microglial inflammatory mediators and is decreased in amygdala of children with autism spectrum disorder

Irene Tsilioni 1, Harry Pantazopoulos 2, Pio Conti 3, Susan E Leeman 4, Theoharis C Theoharides 5 6 7 8 Abstract: Autism spectrum disorder (ASD) is characterized by impaired social interactions and communication. The pathogenesis of ASD is not known, but it involves activation of microglia. We had shown that the peptide neurotensin (NT) is

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IL-37 is increased in brains of children with autism spectrum disorder and inhibits human microglia stimulated by neurotensin

Irene Tsilioni 1, Arti B Patel 1 2, Harry Pantazopoulos 3, Sabina Berretta 3, Pio Conti 4, Susan E Leeman 5, Theoharis C Theoharides 6 2 7 Abstract: Autism spectrum disorder (ASD) does not have a distinct pathogenesis or effective treatment. Increasing evidence supports the presence of immune dysfunction and inflammation in the brains of children with ASD. In this report, we present data that gene expression of the antiinflammatory cytokine

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Substance P and IL-33 administered together stimulate a marked secretion of IL-1β from human mast cells, inhibited by methoxyluteolin

Alexandra Taracanova 1 2, Irene Tsilioni 1, Pio Conti 3, Errol R Norwitz 4, Susan E Leeman 5, Theoharis C Theoharides 6 2 7 Abstract: Mast cells are critical for allergic and inflammatory responses in which the peptide substance P (SP) and the cytokine IL-33 are involved. SP (0.01-1 μM) administered together with IL-33 (30 ng/mL) to human cultured LAD2 mast cells stimulates a

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SP and IL-33 together markedly enhance TNF synthesis and secretion from human mast cells mediated by the interaction of their receptors

Alexandra Taracanova 1 2, Mihail Alevizos 1, Anna Karagkouni 1, Zuiy Weng 1 2, Errol Norwitz 3, Pio Conti 4, Susan E Leeman 5, Theoharis C Theoharides 6 2 7 Abstract: The peptide substance P (SP) and the cytokine tumor necrosis factor (TNF) have been implicated in inflammatory processes. Mast cells are recognized as important in inflammatory responses. Here, we report that IL-33 (30 ng/mL), a member of the IL-1 family of cytokines, administered

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IL-33 augments substance P-induced VEGF secretion from human mast cells and is increased in psoriatic skin

Theoharis C Theoharides, Bodi Zhang, Duraisamy Kempuraj, Michael Tagen, Magdalini Vasiadi, Asimenia Angelidou, Konstantinos-Dionysios Alysandratos, Dimitris Kalogeromitros, Shahrzad Asadi, Nikolaos Stavrianeas, Erika Peterson, Susan Leeman, Pio Conti Abstract: The peptide substance P (SP) has been implicated in inflammatory conditions, such as psoriasis, where mast cells and VEGF are increased. A relationship between SP and VEGF

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